I might want to find quotes with no description, or Contacts of customers with no job title, or divisions of a particular company type that have no sales ledger, or orders with on customer purchase reference, etc, etc.
Nor can you get a list of all divisions that have got a sales ledger, or all contacts that have an email address.
At the moment you cannot do either of those. Adding filter options (most usefully for strings but perhaps for other types too) of filter by "Is Empty" and "Is NOT empty" would be really useful